NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages drive chemoradiotherapy resistance in esophageal squamous cell carcinoma
Jiaying Deng, Zhenzhen Xun, Hu Chen, Yanhong Cen, Yikai Luo, Wei Liu, Weiwei Chen, Junqiang Chen, Jinjun Ye, Xiansu Gao, Qingsong Fan, Jibin Song, Qi Chen, Yuan Li, Fei Ding, , Han Liang
This study identifies NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages as drivers of chemoradiotherapy resistance in ESCC through multi-omics analysis of clinical trial data.
bioRxiv · Feb 21, 2026 · PreprintCancer Biology