Yikai Luo

The paper identifies two resistance mechanisms in gastric cancer to chemo-immunotherapy, involving CEACAM5/6+ tumor cells and IL-1β+ macrophages, and suggests them as biomarkers and therapeutic targets.

This study identifies NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages as drivers of chemoradiotherapy resistance in ESCC through multi-omics analysis of clinical trial data.

The paper identifies ZZEF1 as a tRNA-specific transcription factor that suppresses breast cancer metastasis by regulating tRNA-LysUUU expression and affecting codon-specific translation.

The paper identifies a convergent pattern of amino acid usage in cancers that mirrors reversed tissue development, using ECPA as a biomarker with high accuracy in liver cancer detection.

The paper compiles protein response data from cancer cell lines to drug perturbations, showing improved drug sensitivity prediction and building a protein-drug connectivity map with an accessible data portal.

The paper identifies RBMS1 as a suppressor of colon cancer metastasis by stabilizing its mRNA targets, showing its clinical relevance in patient survival.