Yuan Li

Dynamics-aware geometric learning predicts disease-associated molecular perturbations

This study introduces DynGeo-Pheno, a geometric deep learning framework that predicts disease-associated phosphosites and missense mutations by integrating protein dynamics and structural information.

Generation of human appetite-regulating neurons and tanycytes from stem cells

This study generates human appetite-regulating neurons and tanycytes from stem cells, identifying key progenitor markers and signaling mechanisms for hypothalamic subregion specification.

Engineering autologous ossicles for the personalized modeling of acute myeloid leukemia

This paper introduces OssiGel, a novel engineered matrix that enables the formation of autologous ossicles from AML patient samples, supporting AML cell engraftment and recapitulating patient-specific cellular interactions.

MTDH-SND1 disruption sensitizes ovarian cancer to ferroptosis and PARP inhibition

This study shows that disrupting the MTDH-SND1 complex in BRCA-deficient ovarian cancer increases sensitivity to ferroptosis and PARP inhibition, with potential immune system benefits.

Interactive Effects of Biological Maturation and Relative Age Effect on Talent Identification for U16 Elite Soccer Players

This study examines how biological maturation and relative age effect influence talent identification in U16 elite soccer players, finding significant impacts of maturation on physical and performance metrics but not on selection criteria.

A Conserved Geometric Code: Extracellular Matrix Curvature Directs Cell Migration Strategy via Nuclear Mechanosensing

The paper shows ECM curvature directs cell migration through nuclear mechanosensing, revealing a geometric code influencing migration strategy and metastasis.

Single-cell transcriptomic atlas of mouse oocyte development from growth to ovulation

This study creates a single-cell transcriptomic atlas of mouse oocyte development from growth to ovulation using a new platform and integrates transcriptomic and morphological data to identify temporal shifts in gene expression.

NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages drive chemoradiotherapy resistance in esophageal squamous cell carcinoma

This study identifies NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages as drivers of chemoradiotherapy resistance in ESCC through multi-omics analysis of clinical trial data.

Cardiomyocyte antisense transcription regulates exon usage in the elastic spring region of Titin to modulate sarcomere function

This study shows that TTN-AS1-276 antisense transcript regulates TTN alternative splicing and sarcomere function in cardiomyocytes.

PKD2 influence uric acid levels and gout risk by interacting with ABCG2

This study identifies epistatic interactions between PKD2 and ABCG2 influencing uric acid levels and gout risk, with gender and BMI-dependent effects.

scDD: A statistical approach for identifying differential distributions in single-cell RNA-seq experiments

scDD identifies differential expression patterns in single-cell RNA-seq by modeling complex distribution differences, outperforming existing methods in detecting subtle gene expression changes.