Glucose is a ligand-like trigger for secretion of postprandial GLP-1
Chun Mu Li, Mengqi Li, Heng-Ye Yang, Xiao Tian, Chen‐Song Zhang, Lin Zhao, Jianfeng Wu, Cixiong Zhang, Shiqi Liu, Xiaotong Yang, Xiufeng Sun, Junjie Chen, Baoding Zhang, Chuyu Yun, Jun Lin, , Sheng‐Cai Lin
This study shows glucose directly binds to glucokinase (GK) to trigger GLP-1 secretion in intestinal L cells, independent of ATP levels, and identifies GK and KATP as key players in this process.
bioRxiv · Jan 4, 2026 · PreprintBiochemistry