Junjie Chen

The paper identifies millions of self-cleaving ribozymes in humans and other species, revealing a much larger ribozyme-ome than previously thought and their potential roles in gene regulation and biotechnology.

This study shows glucose directly binds to glucokinase (GK) to trigger GLP-1 secretion in intestinal L cells, independent of ATP levels, and identifies GK and KATP as key players in this process.

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.