Derepression of transposable elements in mouse prefrontal cortex disrupts social behavior
R. Kijoon Kim, Catherine A. Smith, Natalie L. Truby, Shelbey R. Strandberg, Jessica L. Bell, Nic Carwile, Gabriella M. Silva, Rachael L. Neve, Theingi Aung, Xiaohong Cui, Peter J. Hamilton
This study shows that altering TRIM28 function in the mouse prefrontal cortex leads to transposable element derepression and social behavior deficits, which can be reversed by interferon cytokines.
Proceedings of the National Academy of Sciences · Dec 17, 2025Peer-reviewedNeuroscience