Targeting Cardiac Fibrosis with Chimeric Antigen Receptor Neutrophils Derived from Human Pluripotent Stem Cells
Gyuhyung Jin, Shaohai Fang, Yun Chang, Kunming Shao, Huiyang Li, Yan Tan, Xiaojun Lian, Qing Deng, Yun Huang, Xiaoping Bao
This study develops hPSC-derived FAP CAR neutrophils to target cardiac fibrosis, showing in vitro cytotoxicity and improved left ventricular ejection fraction in a mouse MI model.
bioRxiv · Oct 13, 2026 · PreprintBioengineering