Xiaoping Bao

The paper demonstrates how general-purpose AI can analyze public molecular datasets to generate hypotheses and identify biological relationships, though not all findings were validated experimentally.

This study develops hPSC-derived FAP CAR neutrophils to target cardiac fibrosis, showing in vitro cytotoxicity and improved left ventricular ejection fraction in a mouse MI model.

This study identifies extravascular coagulation as a regulator of fibrotic stromal states in PDAC via tumor-intrinsic PAR1 signaling, showing PAR1 inhibition can reprogram the tumor-promoting stroma.

This study uses photo-clickable decellularized matrix hydrogels to generate pancreatic ductal organoids from iPSCs, showing that stiffer hydrogels promote ductal differentiation over mesenchymal.

scChat is a large language model co-pilot for scRNA-seq analysis that integrates contextual reasoning to improve hypothesis generation and experimental design.

This study develops hypoimmunogenic hPSC-derived cardiac organoids that evade immune rejection and repair damaged hearts in animal models.