Tumor-derived stearic acid induces macrophage Egr2 signaling to suppress anti-tumor immunity in breast cancer
Yongling Ning, Caijun Wu, Sailesh Phuyal, Xiaoling Hu, Hong Li, Robert A. Mitchell, Jun Yan, Chuanlin Ding
This study identifies stearic acid-induced Egr2 signaling in macrophages as a mechanism suppressing anti-tumor immunity in breast cancer, with oleic acid inhibiting this effect.
bioRxiv · Jul 21, 2026 · PreprintImmunology