Indazolone-Based Molecular Glue Degraders as a Tunable Platform for Reprogramming Cereblon Substrate Specificity
Hui‐Jun Nie, Jiamin Wang, Hao Xu, Yin-Jue Zhou, Guang‐Liang Yin, Xiaomim Xu, Gaoya Xu, Beijing Chen, Xian Li, Xiaobei Hu, Yubo Zhou, Jia Li, Chen Xiaohua
This paper introduces an indazolone-based platform for CRBN molecular glue degraders, enabling tunable substrate specificity and broad therapeutic potential.
bioRxiv · Mar 25, 2026 · PreprintBiochemistry