Author

Hui‐Jun Nie

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

An‐Di Guo· 1 shared Beijing CheniD· 1 shared Bing YangiD· 1 shared Chen XiaohuaiD· 1 shared Gaoya Xu· 1 shared Guang-Liang Yin· 1 shared Guang‐Liang YiniD· 1 shared Hao HuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

An‐Di Guo

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Author profile →

2 papers

Recent·Most cited

Indazolone-Based Molecular Glue Degraders as a Tunable Platform for Reprogramming Cereblon Substrate Specificity

Hui‐Jun Nie, Jiamin Wang, Hao Xu, Yin-Jue Zhou, Guang‐Liang Yin, Xiaomim Xu, Gaoya Xu, Beijing Chen, Xian Li, Xiaobei Hu, Yubo Zhou, Jia Li, Chen Xiaohua

This paper introduces an indazolone-based platform for CRBN molecular glue degraders, enabling tunable substrate specificity and broad therapeutic potential.

bioRxiv · Mar 25, 2026 · PreprintBiochemistry

Visible-Light-Controlled Residue-Selective Cross-Linking for Deciphering Protein Complexes and Dynamic Protein-Protein Interactions in Live Cells

Yali Xu, Hao Hu, Yu Ran, Wensi Zhao, An‐Di Guo, Hui‐Jun Nie, Linhui Zhai, Guang-Liang Yin, Jintao Cheng, Shengna Tao, Bing Yang, Minjia Tan, Xiaohua Chen

This paper introduces a visible-light-controlled cross-linking method for analyzing protein complexes and dynamic interactions in live cells, showing improved accuracy and temporal control.

bioRxiv · Mar 18, 2025 · PreprintBiochemistry