IgG4⁺ plasma cell enrichment and {lambda}-chain-biased BCR remodeling drive low-grade autoimmunity in chronic obstructive pulmonary disease
Luo Duan, Hongyun Zhao, Yanqi Xia, Xiaoxia Ren, Huanyu Long, Lun Li, Mi Mu, Kaixin Li, Jie Liu, Yunpeng Dou, Ye Cui, Yan Chen, Zhe Lv, Christopher John Corrigan, Sebastian Lennox Johnston, , Ying Sun
This study identifies IgG4⁺ plasma cell enrichment and λ-chain-biased BCR remodeling in COPD, linking them to low-grade autoimmunity and chronic inflammation.
bioRxiv · Jun 30, 2026 · PreprintImmunology