Author

Xiaoyu Chen

BGI Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Bioinformatics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Christopher T. SaundersiD· 2 shared Aaron L. HalperniD· 1 shared Anthony J. Cox· 1 shared Bret Barnes· 1 shared Chuanyu LiuiD· 1 shared Doruk BeyteriD· 1 shared Eunho Noh· 1 shared Fan Zhu· 1 shared

Activity by Year

2015-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBioinformatics

Christopher T. SaundersORCID

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3 papers

Recent·Most cited

Single cell resolved spatial immune repertoire unveils spatial heterogeneity of lymphoid aggregates in human immune disorders

Xiaojuan Zhan, Yi Liu, Yanying Guo, Wenwen Zhou, Yixin Yan, Hui Zeng, Xuan Dong, Xiaoyu Chen, Rong Ma, Zhong Liu, Fan Zhu, Xubin Zheng, Xinxing Li, Jinwen Yin, Francis Ka-Ming Chan, , Yu Feng

This study introduces Stereo-XCR-seq, a method for in situ single-cell T and B cell repertoire sequencing, revealing spatial heterogeneity in lymphoid aggregates in immune disorders.

bioRxiv · Jan 16, 2025 · PreprintImmunology

Strelka2: Fast and accurate variant calling for clinical sequencing applications

Sangtae Kim, Konrad Scheffler, Aaron L. Halpern, Mitchell A. Bekritsky, Eunho Noh, Morten Källberg, Xiaoyu Chen, Yeonbin Kim, Doruk Beyter, Peter Krusche, Christopher T. Saunders

Strelka2 is a variant calling tool that improves accuracy and reduces compute cost for germline and somatic variant detection in clinical sequencing.

Nature Methods · Jul 11, 2018Peer-reviewedBioinformatics

Manta: Rapid detection of structural variants and indels for clinical sequencing applications

Xiaoyu Chen, Ole Schulz-Trieglaff, Richard Shaw, Bret Barnes, Felix Schlesinger, Anthony J. Cox, Semyon Kruglyak, Christopher T. Saunders

Manta rapidly detects structural variants and indels in clinical sequencing by optimizing speed and accuracy for germline and somatic analysis.

Bioinformatics · Dec 8, 2015Peer-reviewedBioinformatics