Author

Bret Barnes

Illumina (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Approach:statistical model· 3 Research Focus:database / resource· 2 Organism:human· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Wanding ZhouiD· 3 shared Rishi PorechaiD· 2 shared Sol Moe LeeiD· 2 shared A ArnesoniD· 1 shared Ake Tzu-Hui LuiD· 1 shared Alexandra VanderArk· 1 shared Amin HaghaniiD· 1 shared Anita PottekatiD· 1 shared

Activity by Year

2015-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersGenomics

Wanding ZhouORCID

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Author profile →

4 papers

Recent·Most cited

Scalable Screening of Ternary-Code DNA methylation Dynamics Associated with Human Traits.

David C. Goldberg, Cameron Cloud, Sol Moe Lee, Bret Barnes, Steven Gruber, Elliot Kim, Anita Pottekat, Maximillian S. Westphal, Luana McAuliffe, Elisa Majounie, Manesh Kalayil Manian, Qingdi Zhu, Christine Tran, Mark S. T. Hansen, Jelena Stojakovic, , Wanding Zhou

The paper introduces MSA, a new epigenotyping platform for analyzing ternary-code DNA methylation, and applies it to uncover aging dynamics and trait associations involving 5hmC and 5mC.

Cell Genomics · Jul 3, 2025Peer-reviewedGenomics

DNA Methylation Dynamics and Dysregulation Delineated by High-Throughput Profiling in the Mouse

Wanding Zhou, Toshinori Hinoue, Bret Barnes, Owen D. Mitchell, Waleed Iqbal, Sol Moe Lee, Kelly K. Foy, Kwang‐Ho Lee, Ethan Jacob Moyer, Alexandra VanderArk, Julie M. Koeman, Wubin Ding, Manpreet Kalkat, Nathan J. Spix, Bryn Eagleson, , Peter W. Laird

This paper develops a high-throughput DNA methylation array and atlas for mice, revealing tissue-specific methylation patterns and their associations with aging, differentiation, and disease.

Cell Genomics · Jul 1, 2022Peer-reviewedGenomics

A mammalian methylation array for profiling methylation levels at conserved sequences

A Arneson, Amin Haghani, Michael James Thompson, Matteo A. Pellegrini, Soo Bin Kwon, Ha Vu, Emily Maciejewski, Mingjia Yao, Caesar Z. Li, Ake Tzu-Hui Lu, Marco Morselli, Liudmilla Rubbi, Bret Barnes, Kasper D. Hansen, Wanding Zhou, , Steve Horvath

The paper develops a mammalian methylation array to profile methylation levels at conserved sequences across species, enabling cross-species comparisons and epigenetic biomarker development.

Nature Communications · Feb 10, 2022Peer-reviewedBioinformatics

Manta: Rapid detection of structural variants and indels for clinical sequencing applications

Xiaoyu Chen, Ole Schulz-Trieglaff, Richard Shaw, Bret Barnes, Felix Schlesinger, Anthony J. Cox, Semyon Kruglyak, Christopher T. Saunders

Manta rapidly detects structural variants and indels in clinical sequencing by optimizing speed and accuracy for germline and somatic analysis.

Bioinformatics · Dec 8, 2015Peer-reviewedBioinformatics