Lineage recording reveals hijacked hepatic progenitor states as a common origin of HCC and ICC
Jinyong Fan, Jiazheng Pei, Nuo Xu, Xiaoyun Wang, Xiaoyun Wang, Shiyu Mao, Yu Zhang, Lisi Yu, Yingxia Sun, Yeqing Gong, Xinyuan Xiong, Shu Wang, Lin Li, Zhen Shao, Xuxu Sun, , Xin Liu
The paper uses CERAMIC to trace liver tumor initiation, identifying Hep_Bi-zonal cells as the origin of HCC and ICC and revealing peroxisomal metabolism and macrophage niches as key factors.
bioRxiv · Jul 30, 2026 · PreprintCancer Biology