Long-term efficacy of adoptive cell therapy is determined by host CD8+ T cells and undermined by lymphodepleting preconditioning
Diego A. Figueroa, Juan Pablo Vega, Andrés Hernández‐Oliveras, Felipe Gálvez‐Cancino, Felipe Ardiles, Felipe Flores, Sofía Hidalgo, Ximena López, Hugo González, Fabiola Osorio, Vincenzo Borgna, Álvaro Lladser
This study shows that host CD8+ T cells enhance adoptive cell therapy (ACT) efficacy against melanoma, while lymphodepleting preconditioning reduces long-term effectiveness by impairing host immunity.
bioRxiv · May 16, 2024 · PreprintImmunology