Author

Hugo González

University of California, San FranciscoORCID 0000-0002-3612-6284Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alan Shen· 1 shared Alexis J. CombesiD· 1 shared Álvaro LladseriD· 1 shared Andrés Hernández‐OliverasiD· 1 shared Annabelle Duflock· 1 shared Claire E. O’LearyiD· 1 shared Diego A. FigueroaiD· 1 shared Eric SmithiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Alan Shen

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

RasGRP1 promotes efficient intestinal tuft cell differentiation

Lauren A. Shechtman, Philippe Depeille, Eric Smith, Hong-Erh Liang, Tammie S. Y. Tam, Annabelle Duflock, Victor S. Cortez, Claire E. O’Leary, Alan Shen, Wouter Bos, Gabriela K. Fragiadakis, Alexis J. Combes, Hugo González, Richard M. Locksley, Jeroen P. Roose

This study identifies RasGRP1 as a regulator of tuft cell differentiation in the intestine, showing it restricts progenitor proliferation and enhances IL-13-driven responses.

bioRxiv · Oct 2, 2026 · PreprintCell Biology

Long-term efficacy of adoptive cell therapy is determined by host CD8+ T cells and undermined by lymphodepleting preconditioning

Diego A. Figueroa, Juan Pablo Vega, Andrés Hernández‐Oliveras, Felipe Gálvez‐Cancino, Felipe Ardiles, Felipe Flores, Sofía Hidalgo, Ximena López, Hugo González, Fabiola Osorio, Vincenzo Borgna, Álvaro Lladser

This study shows that host CD8+ T cells enhance adoptive cell therapy (ACT) efficacy against melanoma, while lymphodepleting preconditioning reduces long-term effectiveness by impairing host immunity.

bioRxiv · May 16, 2024 · PreprintImmunology