An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.
Fang-Xu Li, Sheng Liu, Zhi-Dong Zhang, Xin Shuai, Bi-Kun Xiao, Jia Yang, Defen Lu, Dandan Lin, Guijun Shang, Bo Zhong
This study identifies a mutation that suppresses SAVI phenotypes in MITA/STING gain-of-function mutants and proposes a therapeutic strategy using a peptide inhibitor.
Cell Insight · Jan 8, 2026Peer-reviewedImmunology