Bo Zhong

An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.

This study identifies a mutation that suppresses SAVI phenotypes in MITA/STING gain-of-function mutants and proposes a therapeutic strategy using a peptide inhibitor.

Tumor cell-specific loss of GPX4 reprograms triacylglycerol metabolism to escape ferroptosis and impair antitumor immunity in NSCLC

This study shows that GPX4 loss in tumor cells promotes NSCLC by reprogramming lipid metabolism and suppressing antitumor immunity through ferroptosis evasion and immunoinhibitory TME.