RNF25 restrains GCN2 hyperactivation to sustain protein synthesis and cell proliferation in response to RNA damage
Antonia S. Seidel, Lucia Nemcekova, Martin Grønbæk-Thygesen, Xinyao Shi, Sofia Ramalho, Kelly Mordente, Simon Bekker‐Jensen, Peter Haahr
This study identifies RNF25 as a regulator of GCN2 activity during RNA damage, showing that RNF25 prevents excessive GCN2 activation to maintain protein synthesis and cell proliferation.
bioRxiv · Mar 24, 2026 · PreprintCell Biology