Martin Grønbæk-Thygesen

This study identifies RNF25 as a regulator of GCN2 activity during RNA damage, showing that RNF25 prevents excessive GCN2 activation to maintain protein synthesis and cell proliferation.

The paper identifies BAG6 and RNF126 as key players in PQC degradation of non-native missense protein variants using CRISPR screens and VAMP-seq.

This study shows that ubiquitylation of UBQLN2's UBL domain regulates its stability and localization, with implications for proteasomal degradation and ALS.

The paper systematically identifies degrons in human cytosolic proteins and links them to disease mechanisms through machine learning and structural analysis.

The paper uses deep mutational scanning to show that protein degradation and toxicity are tightly correlated in ASPA variants linked to Canavans disease.

The paper shows that BHD-linked FLCN variants cause loss of function via proteasomal degradation and misfolding, with potential therapeutic implications for stabilization.