5-azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia
Boyang Gao, Ying Li, Xinyuan Ma, Long Zhao, Zhongyu Zou, Juyeong Hong, Junhong Xiang, Xiaoyang Dou, Feng‐Chun Yang, Mingjiang Xu, Chuan He
This paper shows that 5-azaC induces leukemia cell death by depleting m5C in chromatin-associated RNA, leading to transcriptional repression and disrupting key regulatory pathways.
Molecular Cell · Sep 1, 2026Peer-reviewedMolecular Biology