Xiaoyang Dou

This paper shows that 5-azaC induces leukemia cell death by depleting m5C in chromatin-associated RNA, leading to transcriptional repression and disrupting key regulatory pathways.

The paper reveals an m6A-dependent mechanism where microRNAs bind chromatin-associated RNAs to activate transcription by recruiting chromatin remodelers and demethylases.

This study shows that LINE1 RNA dysregulation impairs chromatin accessibility in ALS/FTD, leading to transcriptional changes and neuronal dysfunction.

The paper links cellular developmental potency to genomic transcriptional potency, showing that gene occlusion via chromatinization restricts lineage potential.