An ancient transcription factor functions as the master regulator of primary cilia formation
Weihua Wang, Xiqi Zhang, Yi Qiu, Xiangrui Meng, Sitong Cheng, Yutong Chen, Siqi Liu, Wenhui Chen, Jiayan Yi, Xiwen You, Hongni Liu, Junqiao Xing, Cheng Xu, Haochen Jiang, Haibo Wang, , Zhangfeng Hu
This study identifies Xap5 as a master regulator of primary cilia formation by interacting with Nono to activate Sox5 and Sox9, revealing a conserved transcriptional network involved in ciliary diversity.
bioRxiv · Nov 28, 2025 · PreprintCell Biology