A unified eIF1A+ luminal cells-centered hypoxic and "cold" tumor microenvironment promotes PCa progression among different subtypes
Lilin Wan, Enyao Huang, Xu Zicheng, Bing Zheng, Xuefei Ding, Chunyan Chu, Tiange Wu, Shengrong Chen, J. Zhuang, Ming Chen, Rong Na, Shenghong Ju, Dingxiao Zhang, Wenchao Li, Yifei Cheng, Bin Xu
This study identifies a hypoxic eIF1A+ luminal cell cluster in prostate cancer that promotes tumor progression and creates an immunosuppressive microenvironment, with potential therapeutic implications.
bioRxiv · Apr 17, 2025 · PreprintCancer Biology