Ming Chen

The paper creates a spatially-resolved human brain proteome atlas, revealing protein diversity and functional specialization, and identifies therapeutic targets in epilepsy.

In THP-1 cells, hypoxia drives Lyn-dependent YY1 phosphorylation and phase separation; YY1 and NUSAP1 SUMOylate and stabilize HIF-1α, and degrading YY1 curbs mouse prostate tumors.

This study identifies a hypoxic eIF1A+ luminal cell cluster in prostate cancer that promotes tumor progression and creates an immunosuppressive microenvironment, with potential therapeutic implications.

This paper introduces RBET, a statistical framework to evaluate batch correction methods for single-cell transcriptomic data integration, showing it selects optimal tools for accurate downstream analysis.