Shenghong Ju

In THP-1 cells, hypoxia drives Lyn-dependent YY1 phosphorylation and phase separation; YY1 and NUSAP1 SUMOylate and stabilize HIF-1α, and degrading YY1 curbs mouse prostate tumors.

This study identifies a hypoxic eIF1A+ luminal cell cluster in prostate cancer that promotes tumor progression and creates an immunosuppressive microenvironment, with potential therapeutic implications.

This study uses in vivo imaging to show microglia surveillance is coupled to sleep-wake cycles and stress, with norepinephrine signaling playing a key role.