Wenchao Li

This study identifies VARS1 as a driver of prostate cancer progression by altering codon usage in translation, showing that targeting VARS1 can suppress tumor growth through dietary valine restriction or inhibitors.

In THP-1 cells, hypoxia drives Lyn-dependent YY1 phosphorylation and phase separation; YY1 and NUSAP1 SUMOylate and stabilize HIF-1α, and degrading YY1 curbs mouse prostate tumors.

This study identifies a hypoxic eIF1A+ luminal cell cluster in prostate cancer that promotes tumor progression and creates an immunosuppressive microenvironment, with potential therapeutic implications.