Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor Phenotypes
Thomas A. Kluiver, Anna Nordin, Yuyan Lu, Xuan Guo, Stephanie A Schubert, Darien Yeung, Arif Ibrahim Ardisasmita, Wessel Terpstra, Chang Zhang, Xiaochen Duan, Rishi Savur, M. E. N. van den Heuvel, Vincent Erwin de Meijer, Ruben H. de Kleine, Kathelijne C.J.M. Kraal, , Weng Chuan Peng
The paper identifies how differential TCF7L2/LEF1 binding specificity of {beta}-catenin shapes distinct gene regulatory outcomes in liver tumors.
bioRxiv · Nov 4, 2025Cancer Biology