Claudio Cantù

This study shows Wnt/β-catenin signaling can establish new regulatory elements by remodeling chromatin, beyond its traditional role as a molecular switch.

The paper shows GATA transcription factors modulate Wnt/β-catenin signaling to control cell identity in the intestinal epithelium by repressing secretory lineage genes in stem cells.

This paper introduces CUT&ID, a method that simultaneously profiles protein-DNA and protein-protein interactions without requiring transgenesis.

The paper identifies how differential TCF7L2/LEF1 binding specificity of {beta}-catenin shapes distinct gene regulatory outcomes in liver tumors.

This study identifies GRHL2 as a co-regulator of PR in breast cancer cells, showing their interaction and shared regulation of gene enhancers through chromatin looping.

The paper identifies SOX2 and NR2F1 as regulators of gene expression in the early postnatal visual thalamus, showing their shared target genes and regulatory mechanisms.

The paper maps transcription factor binding across mouse tissues at different developmental stages, revealing tissue-specific activity and conserved regulatory regions with functional relevance in humans.

This study shows that Wnt signaling changes CTCF binding and chromatin structure by creating new CTCF binding sites that depend on β-catenin.

This study identifies TBX3 as a functional component of the Wnt/β-catenin complex in human colorectal cancer, showing it modulates metastasis-related transcription through direct protein interactions.

ICEBERG identifies genome-wide binding events of transcriptional regulators by using extensive CUT&RUN replicates, revealing previously undetectable events in colorectal cancer.

The paper examines single-cell Wnt signaling responses in human embryonic stem cells and finds that Wnt target gene activation varies among cells, showing uncoupling in gene expression patterns.

The paper identifies CUT&RUN-specific problematic genomic regions, called blacklists, which persist despite standard quality control measures and improve peak calling reliability when removed.

The paper shows that β-catenin binds different genomic loci over time, leading to cell-type specific chromatin responses termed plastic or elastic during Wnt signaling.

The paper introduces a modified CUT&RUN protocol, LoV-U, to reliably profile β-catenin binding and identifies its tissue-specific target genes in human and mouse cells.

This study identifies FOXQ1 as a bimodal activator of Wnt/β-catenin signalling, functioning through TCF/LEF factors and independent mechanisms.

This study identifies Fos as a key regulator of neural stem cell self-renewal, showing it rescues proliferation and interacts with Sox2 through a gene regulatory network involving Socs3.

The paper identifies TBX3 as a tissue-specific component of the Wnt/β-catenin enhanceosome, showing its role in transcriptional regulation and metastasis in colorectal cancer.