Weng Chuan Peng

The paper develops an in vitro MASH model to study metabolite crosstalk between Kupffer cells and hepatocytes, identifying itaconate as a key mediator of liver disease progression.

The paper identifies how differential TCF7L2/LEF1 binding specificity of {beta}-catenin shapes distinct gene regulatory outcomes in liver tumors.

This paper develops a method to detect tumor-specific gene fusions in pediatric cancer by integrating RNA-seq and WGS, identifying 165 high-confidence fusions and their structural variants.

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.