Atypical activation and molecular glue-like dimerization mechanism of an intrinsically-biased chemokine receptor
Nilanjana Banerjee, Manisankar Ganguly, Ashna Reyaz, Sudha Mishra, Annu Dalal, Xue Guo, Xingyu Qiu, Max Meyrath, Christie B. Palmer, Hongchen Guo, Siyuan Song, Shachie Sinha, Nabarun Roy, Debdatta Mukherjee, Divyanshu Tiwari, , Arun K. Shukla
This study reveals an atypical activation mechanism of CXCR7, identifies its role as an opioid receptor, and highlights potential for novel pain therapeutics.
bioRxiv · Oct 30, 2025 · PreprintBiochemistry