Author

Shachie Sinha

Indian Institute of Technology Kanpur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Annu Dalal· 2 shared Arun K. ShuklaiD· 2 shared Manisankar Ganguly· 2 shared Ramanuj BanerjeeiD· 2 shared Sudha MishraiD· 2 shared Amir MotmaeniD· 1 shared Amrita Nallathambi· 1 shared Ana-Maria BratovianuiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Annu Dalal

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2 papers

Recent·Most cited

Atypical activation and molecular glue-like dimerization mechanism of an intrinsically-biased chemokine receptor

Nilanjana Banerjee, Manisankar Ganguly, Ashna Reyaz, Sudha Mishra, Annu Dalal, Xue Guo, Xingyu Qiu, Max Meyrath, Christie B. Palmer, Hongchen Guo, Siyuan Song, Shachie Sinha, Nabarun Roy, Debdatta Mukherjee, Divyanshu Tiwari, , Arun K. Shukla

This study reveals an atypical activation mechanism of CXCR7, identifies its role as an opioid receptor, and highlights potential for novel pain therapeutics.

bioRxiv · Oct 30, 2025 · PreprintBiochemistry

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

Edin Muratspahić, David Feldman, David E. Kim, Xiangli Qu, Ana-Maria Bratovianu, Paula Rivera-Sánchez, Jan Hendrik Voss, Emil Peter Thrane Hertz, Mads Jeppesen, Federica Dimitri, Kensuke Sakamoto, Amrita Nallathambi, Pia Peceli, Jianjun Cao, Brian P. Cary, , David A. Baker

This paper presents computational methods for designing GPCR-binding miniproteins and validates them through high-throughput screening, producing agonists and antagonists for multiple GPCRs.

bioRxiv · Mar 23, 2025 · PreprintBioengineering