Design, synthesis, and pharmacological evaluation of novel PROTAC degraders targeting 11β-HSD1 for metabolic disease intervention
Liguo Wang, Xue Tao, Ming He, Yu Lu, Yuji Wang, Juanjuan Zhu
This study develops and evaluates PROTAC degraders targeting 11β-HSD1, showing improved glucose tolerance and insulin secretion in a T2DM mouse model.
Bioorganic Chemistry · Mar 6, 2026Peer-reviewedBiochemistry