Author

Yuji Wang

Capital Medical UniversityORCID 0000-0003-3842-7627Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Assay:protein structure· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Bin XiiD· 3 shared Bo HuangiD· 3 shared Han WangiD· 3 shared Wenbiao ZhouiD· 3 shared Zhenming LiuiD· 3 shared Bowen ZhangiD· 2 shared Daohua JiangiD· 2 shared Fan FaniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioinformatics

Bin XiORCID

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4 papers

Recent·Most cited

BiochemistryBioorganic ChemistryPeer-reviewedMar 6, 2026

Design, synthesis, and pharmacological evaluation of novel PROTAC degraders targeting 11β-HSD1 for metabolic disease intervention

Liguo Wang, Xue Tao, Ming He…·Juanjuan Zhu

This study develops and evaluates PROTAC degraders targeting 11β-HSD1, showing improved glucose tolerance and insulin secretion in a T2DM mouse model.

1 citation

mouseexperimental assay

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BioinformaticsNature CommunicationsPeer-reviewedFeb 7, 2026

Assessing Conformation Validity and Rationality of Deep Learning-Generated 3D Molecules

Fan Fan, Bin Xi, Xianghu Meng…·Bo Huang

This paper introduces a two-stage method to evaluate 3D molecule conformations generated by AI, achieving high speed and quantum mechanical accuracy.

2 citations

protein structuredeep learning

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BioinformaticsbioRxivPreprintNov 13, 2025

A unified language model bridging de novo and fragment-based 3D molecule design delivers potent CBL-B inhibitors for cancer treatment

Han Wang, Guocheng Sun, Bowen Zhang…·Bo Huang

3 citations

deep learningdrug response / drug discovery

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BioinformaticsbioRxivPreprintSep 23, 2025

Pocket-based molecule generation with an SE(3)-equivariant language model leads to a potent and selective HPK1 inhibitor with in vivo efficacy

Bin Xi, Han Wang, Guocheng Sun…·Bo Huang

1 citation

protein structuredeep learning

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