Liguo Wang

This study evaluates the physicochemical compatibility and stability of urapidil-propofol admixtures during simulated Y-site administration, finding that mixing ratios and diluents affect physical compatibility but chemical stability remains acceptable.

This study develops and evaluates PROTAC degraders targeting 11β-HSD1, showing improved glucose tolerance and insulin secretion in a T2DM mouse model.

This paper introduces Deepeptide, a deep learning pipeline that identifies therapeutic oligopeptides for metabolic diseases, finding 62% of candidates show significant in vitro bioactivity comparable to first-line drugs.

This study reveals a structural mechanism for thermosensing in TRPV3 channels, showing that extreme thermosensitivity arises from protein unfolding and dynamic changes rather than localized sensors.

SwinCell is a 3D transformer-based framework that improves segmentation of dense cellular images by balancing local feature recognition and contextual understanding.

CryoTEN improves cryo-EM density maps using a transformer-based model, achieving better quality and faster performance than existing methods.

The paper identifies non-mutational p53 functional deficiency in TP53 wild-type tumors using SVM models, revealing significant functional impairment and clinical implications.

This study uses single cell multiomic analyses to show DNMT3A mutations in clonal hematopoiesis worsen inflammatory outcomes in COVID-19 by increasing IL32 expression and chromatin accessibility.

This study identifies PRKCG as a glioma biomarker through multi-omics integration, showing its association with glioma progression and survival outcomes when combined with MGMT.

This study characterizes long non-coding RNAs (lncRNAs) by analyzing feature relationships and introduces LGC, an algorithm that accurately identifies lncRNAs across species without prior knowledge.

CircularLogo visualizes intra-motif dependencies in DNA/RNA sequences through an interactive web application.

The paper identifies widespread homozygous deletions of interferon and defensin genes in human cancers, linked to poor patient survival and altered TNF/IFNγ gene expression.