Single-cell multiplex chromatin and RNA interactions in aging human brain
Xingzhao Wen, Zhifei Luo, Wenxin Zhao, Riccardo Calandrelli, Tri C. Nguyen, Xueyi Wan, John Lalith Charles Richard, Sheng Zhong
The paper introduces MUSIC, a technique to profile chromatin interactions, gene expression, and RNA-chromatin associations in single cells, revealing age-related changes and disease associations in human brain samples.
bioRxiv · Jun 28, 2023 · PreprintGenomics