Riccardo Calandrelli

Regulation of Nuclear Transcription by Mitochondrial RNA

The paper identifies mitochondrial RNAs (mtRNAs) as chromatin-associated RNAs (caRNAs) that regulate nuclear transcription in response to stress and disease.

Genome-wide analysis of the interplay between chromatin-associated RNA and 3D genome organization in human cells

This study investigates how chromatin-associated RNA interacts with 3D genome organization in human cells, revealing a feedback loop between RNA distribution and chromatin structure.

Single-cell multiplex chromatin and RNA interactions in aging human brain

The paper introduces MUSIC, a technique to profile chromatin interactions, gene expression, and RNA-chromatin associations in single cells, revealing age-related changes and disease associations in human brain samples.

Sequential increase of PHGDH expression with Alzheimer's pathology and symptoms

The paper shows PHGDH expression increases sequentially with AD pathology and symptoms in mice and humans, correlating with cognitive decline and suggesting PHGDH as a potential biomarker and caution for L-serine therapy.

Dynamic changes in RNA-chromatin interactome promote endothelial dysfunction

The paper investigates how RNA-chromatin interactions change in endothelial cells under high-glucose and TNF treatment, showing their role in inflammation and endothelial dysfunction.

GITAR: an Open Source Tool for Analysis and Visualization of Hi-C Data

GITAR provides a software tool for Hi-C data analysis, including preprocessing, normalization, visualization, and TADs analysis, with a library of processed datasets.

Rainbow-seq: combining cell lineage tracking with single-cell RNA sequencing in preimplantation embryos

Rainbow-seq combines lineage tracing with single-cell RNA-seq to track cell division history and reveal transcriptome differences in mouse embryos.