Serotonin Reuptake Inhibition Reduces NMDAR-Associated Reward Liability Without Compromising Rapid Antidepressant Efficacy
Libiao Pan, Guan Wang, Jing Ji, Yuting Cai, Yingting Pang, Yanmei Chen, Qiaohui Lu, Xuhua Tang, Zhengtao Hu, Baiyang Zheng, Yangyang Xiang, Qiongqiong Hou, Ke Nie, jiangyu zhao, Tianwen Hu, , Jingshan Shen
This study shows that combining serotonin reuptake inhibition with NMDAR antagonism reduces reward-related effects while maintaining rapid antidepressant efficacy.
bioRxiv · Nov 9, 2026 · PreprintNeuroscience