Nucleobase Methylation Enhances SARS-CoV-2 Chain Terminator Evasion of Exonuclease Proofreading
Lin Yang, Rory Cunnison, Carmen Ka Man Tse, Tiantian Xu, Buyu Zhang, Rick Xinzhou Xu, Benny Zhibin Liang, Xunyu Zhou, Danielle Groves, Adrian Deng, Jeremy R Keown, Daqi Yu, Mingyuan Li, Yuanliang Zhai, Billy Wai-Lung Ng, , Peter Pak‐Hang Cheung
This study identifies 5-methyl-3'-dUTP as a nucleoside analogue that effectively terminates RNA chains and resists SARS-CoV-2 exoribonuclease proofreading.
bioRxiv · Sep 20, 2024 · PreprintMicrobiology