Lack of ancestral SARS-CoV-2 imprinting promotes BA.3.2.2 infection in children
Xiao Niu, Dan Xiong, Peizhuo He, Lingling Yu, Y L Li, X L Cai, Ran An, Yao Wang, Rui Kong, Yuanling Yu, Jing Wang, Qianran Wang, Juan Huang, Binmao Zhang, Tianyuan Zhao, , Yunlong Cao
This study shows that the lack of ancestral SARS-CoV-2 immune imprinting in children makes them more susceptible to BA.3.2.2 infection, as it evades neutralizing antibodies typically present in adults.
Nature Microbiology · Oct 26, 2026Peer-reviewedImmunology