Yunlong Cao

This study shows that the lack of ancestral SARS-CoV-2 immune imprinting in children makes them more susceptible to BA.3.2.2 infection, as it evades neutralizing antibodies typically present in adults.

This paper introduces a novel 19F-labeled probe, BTMB, for studying GPCR conformational dynamics and demonstrates its advantages over existing probes through molecular dynamics simulations.

The paper shows that the SARS-CoV-2 variant PJ.2.1 has high ACE2-binding capability but limited immune evasion, suggesting structural changes that may enable future immune escape.

This study evaluates the antibody evasion and receptor binding of SARS-CoV-2 variants PQ.16.1.1 and RK.1, finding reduced ACE2 engagement but increased immune evasion.

This study identifies a hierarchical activation threshold in RSV F antibody repertoires, explaining pediatric vulnerability and adult protection through distinct antibody subclasses and epitope targeting.

cf-Cabernet improves cfDNA methylation sequencing by repairing nicks before end repair, preserving methylation information and outperforming standard methods.

This study determines cryo-EM structures of B0AT2 to elucidate substrate recognition and allosteric inhibition mechanisms, revealing conserved intracellular cavities across SLC6 transporters.

This study shows that V(D)J-humanized mice can replicate severe SARS-CoV-2 immune imprinting in humans, revealing that pre-existing antibody abundance influences imprinting severity.

The paper analyzes pangolin coronaviruses to identify a key immuno-evasive mutation at spike residue 519, similar to SARS-CoV-2, suggesting independent spillover events from bat reservoirs.

The paper isolates human monoclonal antibodies against SFTSV Gn, identifies four neutralizing epitope groups, and validates their neutralization through structural analysis.

Anti-IL1RAP antibodies block multiple IL-1 family cytokines simultaneously, showing superior efficacy in inflammation and cancer models.

This study identifies ACE2 diversity in horseshoe bats and shows bidirectional evolutionary shaping between ACE2 and sarbecovirus spike proteins.

DeepCoV predicts SARS-CoV-2 variant dominance and evolution using DMS data and epidemiological surveillance, achieving high accuracy and capturing spatiotemporal dynamics.

The paper identifies hedgehog APN as a receptor for EriCoVs and shows convergent evolution in its utilization among merbecoviruses.

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.

SARS-CoV-2 variant BA.3.2 strongly evades neutralizing antibodies but exhibits low infectivity due to a closed spike conformation, whereas NB.1.8.1 combines high ACE2 affinity with humoral immune escape.

The paper introduces Joint-Cabernet, a single-cell platform for profiling 5hmC and 5mC, and applies it to mouse brain nuclei to study DNA hydroxymethylation changes with aging.

The paper analyzes virological and antigenic traits of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1, finding trade-offs between immune evasion and ACE2 binding efficiency.

This study investigates the structural and molecular basis of enhanced ACE2 binding in SARS-CoV-2 KP.3 variant through Cryo-EM and MD simulations, revealing synergistic mutational effects.

This study shows that SARS-CoV-2 variants KP.3.1.1 and XEC have enhanced immune evasion through NTD glycosylation, despite maintaining high ACE2 binding and infectivity.

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

The paper investigates how Omicron-specific naive B cell maturation after breakthrough infection alleviates immune imprinting from inactivated SARS-CoV-2 vaccines.

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

This study investigates how N354 glycosylation in the SARS-CoV-2 spike protein affects viral fitness and human adaptation through multiple mechanisms.

The paper compares SARS-CoV-2 variants from China and other countries, finding that Chinese variants have more dispersed RBD mutations with higher ACE2 binding and less immune evasion potential due to a distinct immune background.

This study assesses the antigenic properties and immune evasion of the SARS-CoV-2 variant BA.2.87.1, finding it less resistant to neutralizing antibodies than JN.1 but with compensatory deletions in the NTD.

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

This paper proposes a penalized semiparametric estimator for causal inference with invalid instruments and unmeasured confounders, showing robustness and unbiasedness through simulations and real data.

The paper introduces Cabernet, a bisulfite-free single-cell method for high-resolution 5mC and 5hmC profiling, revealing epigenetic dynamics in mouse embryos and demonstrating scalability for complex tissues.

MINERVA enables rapid, high-quality SARS-CoV-2 whole genome sequencing from clinical samples by simplifying library preparation and improving viral enrichment.