Xiao Niu

Lack of ancestral SARS-CoV-2 imprinting promotes BA.3.2.2 infection in children

This study shows that the lack of ancestral SARS-CoV-2 immune imprinting in children makes them more susceptible to BA.3.2.2 infection, as it evades neutralizing antibodies typically present in adults.

Mouse V(D)J Humanization Recapitulates human-like Severe SARS-CoV-2 Immune Imprinting

This study shows that V(D)J-humanized mice can replicate severe SARS-CoV-2 immune imprinting in humans, revealing that pre-existing antibody abundance influences imprinting severity.

Genetic diversity in horseshoe bat ACE2 and sarbecovirus spike proteins mutually shape one another

This study identifies ACE2 diversity in horseshoe bats and shows bidirectional evolutionary shaping between ACE2 and sarbecovirus spike proteins.

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.