Y. Danger

Single-hit genome edition for expression of single-chain immunoglobulins by edited B cells

This paper develops a method to redirect B cells to express single-chain immunoglobulins by editing a single genomic locus, validated in cell lines and primary B cells.

Serine 165 Phosphorylation of SHARPIN regulates the Activation of NF-κB

The paper shows that phosphorylation of SHARPIN at serine 165 is required for optimal NF-κB activation, despite not affecting linear ubiquitin chain formation.