T. Douanne

The Necroptosis Effector MLKL drives Small Extracellular Vesicle Release and Tumour Growth in Glioblastoma

This study identifies MLKL as a regulator of EV release from GSCs, showing its role in promoting tumour growth and suggesting EV targeting as a therapeutic strategy.

Serine 165 Phosphorylation of SHARPIN regulates the Activation of NF-κB

The paper shows that phosphorylation of SHARPIN at serine 165 is required for optimal NF-κB activation, despite not affecting linear ubiquitin chain formation.

The LUBAC participates in Lysophosphatidic Acid-induced NF-κB Activation

This study shows that LUBAC is essential for LPA-induced NF-κB activation through MALT1-mediated cleavage of HOIL1 and GEF-H1-dependent regulation.

Control of the Endo-Lysosome Homeostasis by the Paracaspase MALT1 regulates Glioma Cell Survival

This study shows that MALT1 regulates endo-lysosome homeostasis and glioma cell survival, with MALT1 inhibition leading to lysosomal-mediated cell death.

Pannexin-1 Channels govern the Generation of Necroptotic small Extracellular Vesicles

The paper identifies MLKL-induced activation of PANX1 channels as a mechanism driving necroptosis-associated small extracellular vesicle generation.