Platycodin D prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection in vitro by hindering membrane fusion
T. Y. Kim, S. Jeon, Y. Jang, L. Gotina, J. Won, Y. H. Ju, S. Kim, M. W. Jang, W. Won, M. G. Park, A. N. Pae, S. Han, S. Kim, C. J. Lee
This study shows that platycodin D inhibits SARS-CoV-2 infection by blocking lysosome- and TMPRSS2-driven entry through membrane cholesterol redistribution.
bioRxiv · Dec 22, 2020Pharmacology & Toxicology