Detecting and Quantitating Low Fraction DNA Variants with Low-Depth Sequencing
P. Song, S. X. Chen, Y. H. Yan, A. Pinto, L. Y. Cheng, P. Dai, A. A. Patel, D. Y. Zhang
This paper introduces mBDA, a method to detect low-frequency DNA variants with low-depth sequencing, and applies it to find tumor heterogeneity in melanoma samples.
bioRxiv · Apr 26, 2020 · PreprintBioengineering