Author

D. Y. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cancer Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:variant calling· 2

Frequent Co-Authors

D. M. O'Rourke· 2 shared G.-l. Ming· 2 shared H. Song· 2 shared L. Y. Cheng· 2 shared X. Wang· 2 shared Z. A. Binder· 2 shared A. A. Patel· 1 shared A. B. Heimberger· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

D. M. O'Rourke

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Brain-wide neuronal circuit connectome of human glioblastoma

Y. Sun, X. Wang, D. Y. Zhang, Z. Zhang, J. P. Bhattarai, Y. Wang, W. Dong, F. Zhang, K. H. Park, J. Galanaugh, A. Sambangi, Q. Yang, S. H. Kim, G. Wheeler, T. Goncalves, , H. Song

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

bioRxiv · Mar 1, 2024Cancer Biology

Screening and Development of Constitutively Synergistic Combination Drug Formulations for T Cell Acute Lymphoblastic Leukemia

J. M. Kelvin, D. Y. Zhang, E. K. Williams, S. G. Moore, L. A. Birnbaum, H. Zecca, X. Wang, J. Jain, M. Qui, N. T. Jui, H. Fu, Y. Du, M. L. Kemp, W. A. Lam, D. DeRyckere, , E. C. Dreaden

The paper identifies synergistic drug combinations for T-ALL using high-throughput screens and develops lipid nanoparticle formulations that maintain drug synergy and improve anti-leukemic activity.

bioRxiv · Sep 21, 2022 · PreprintBioengineering

Single Tube qPCR detection and quantitation of hotspot mutations down to 0.01% VAF

K. Zhang, L. Rodriguez, L. Y. Cheng, D. Y. Zhang

This paper introduces As-BDA, a method that detects and quantifies rare mutations down to 0.01% VAF using qPCR, with high concordance compared to ddPCR.

bioRxiv · Aug 12, 2021 · PreprintBioengineering

High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

R. Thokala, Z. A. Binder, Y. Yin, L. Zhang, J. V. Zhang, D. Y. Zhang, M. C. Milone, G.-L. Ming, H. Song, D. M. O'Rourke

This paper develops a CAR T cell with broad EGFR specificity to target multiple tumor clones and reduce antigen loss escape in glioblastoma.

bioRxiv · Feb 4, 2021Cancer Biology

Prefusion spike protein stabilization through computational mutagenesis

D. Y. Zhang, J. Wang, N. V. Dokholyan

The paper develops a pipeline to identify thermodynamically stabilizing mutations in the SARS-CoV-2 spike protein using bioinformatics, molecular dynamics, and a protein design tool.

bioRxiv · Jun 17, 2020Biophysics

Detecting and Quantitating Low Fraction DNA Variants with Low-Depth Sequencing

P. Song, S. X. Chen, Y. H. Yan, A. Pinto, L. Y. Cheng, P. Dai, A. A. Patel, D. Y. Zhang

This paper introduces mBDA, a method to detect low-frequency DNA variants with low-depth sequencing, and applies it to find tumor heterogeneity in melanoma samples.

bioRxiv · Apr 26, 2020 · PreprintBioengineering

Donut PCR: a rapid, portable, multiplexed, and quantitative DNA detection platform with single-nucleotide specificity

D. Khodakov, J. Li, J. X. Zhang, D. Y. Zhang

bioRxiv · Apr 24, 2020Bioengineering

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

J. R. Kane, J. Zhao, T. Tsujiuchi, B. Laffleur, A. Mahajan, G. Rao, A. Mela, C. Dmello, V. A. Arrieta, L. Chen, D. Y. Zhang, E. Gonzalez-Buendia, C. Lee-Chang, T. Xiao, G. Rothschild, , A. M. Sonabend

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.

bioRxiv · Jul 16, 2019Cancer Biology