Y. L. Lyubchenko

The Interaction of NF-κB Transcription Factor with Centromeric Chromatin

This study investigates how NF-κB interacts with H3nuc and CENP-Anuc, finding that it unravels H3nuc but not CENP-Anuc.

Nanoscale Structure, Interactions, and Dynamics of Centromere Nucleosomes

This study uses AFM to analyze the nanoscale structure and dynamics of CENP-A and canonical H3 nucleosomes, revealing differences in internucleosomal interactions and DNA unwrapping behavior.

Nanoscale interaction of endonuclease APE-1 with DNA characterized by atomic force microscopy

This study uses atomic force microscopy to visualize APE1-DNA interactions, revealing APE1's affinity for G-rich DNA and its ability to form loops between DNA segments.

Assembly of Synaptic Protein-DNA Complexes: Critical Role of Non-Specific Interactions

The paper investigates the stability of SfiI-DNA complexes using single-molecule fluorescence and develops a theoretical model to explain the role of non-specific DNA interactions in synaptic protein-DNA complex assembly.

Sequence Dependent Internucleosomal Interactions Dominate Array Assembly

This study investigates how DNA sequence and internucleosomal interactions influence nucleosome array compaction using Atomic Force Microscopy and develops a theoretical model to explain the results.

Restriction of RecG translocation by DNA mispairing

This study investigates how DNA mispairing affects RecG helicase translocation using AFM, finding that certain mismatches block movement while others do not.

Transcription Factor NF-κB Unravels Nucleosomes

This study uses Atomic Force Microscopy to investigate how NF-κB interacts with nucleosomes, revealing two binding modes and suggesting a role for NF-κB as a pioneer factor.

Cholesterol in membranes facilitates aggregation of amyloid beta protein at physiologically low concentrations

This study shows cholesterol in membranes enhances Aβ42 aggregation at low concentrations through AFM imaging and computational modeling.

High-Speed AFM directly visualizes conformational dynamics of the HIV-Vif protein complex

This study uses high-speed AFM to visualize conformational dynamics of the HIV-Vif protein complex, identifying three stable structures and characterizing their dynamics.

AFM characterization of the interaction of PriA helicase with stalled DNA replication forks

This study uses AFM to examine how PriA helicase interacts with stalled DNA replication forks in the presence or absence of SSB, revealing specific binding preferences and remodeling roles.

Spontaneous Self-assembly of Amyloid β (1-40) into Dimers

This study uses molecular dynamics simulations to show that Aβ(1-40) monomers form stable dimers through specific inter-peptide interactions, without forming long β-strands typical of fibrils.

Nanoscale Dynamics of Centromere Nucleosomes and the Critical Roles of CENP-A

This study uses high-speed atomic force microscopy to observe CENP-A nucleosome dynamics, revealing spontaneous conformational changes and unique stabilization properties compared to H3 cores.