P. Bianco

An integrated picture of the structural pathways controlling the heart performance

The paper revises the mechanosensing hypothesis of heart function using X-ray diffraction data and cryo-EM structures, identifying structural changes in thick filaments that modulate motor activation and heart performance.

Titin switches from an extensible spring to a mechanical rectifier upon muscle activation

The paper investigates titin's mechanical behavior in frog muscle during activation, finding it transitions from an extensible spring to a mechanical rectifier.

Restriction of RecG translocation by DNA mispairing

This study investigates how DNA mispairing affects RecG helicase translocation using AFM, finding that certain mismatches block movement while others do not.

SSB facilitates fork substrate discrimination by PriA

This study shows SSB enhances PriA's ability to discriminate between replication fork substrates by 140-fold, ensuring accurate replication restart.

A myosin II-based nanomachine devised for the study of Ca2+-dependent mechanisms of muscle regulation

This paper describes a synthetic nanomachine using myosin II and actin to study Ca2+-dependent muscle regulation mechanisms, showing consistent power output across Ca2+ concentrations.

α-catenin switches between a slip and an asymmetric catch bond with F-actin to cooperatively regulate cell junction fluidity

This study shows that -catenin forms different types of bonds with F-actin depending on its dimerization state and applied force, affecting cell junction fluidity.

Super-resolution imaging reveals changes in Escherichia coli SSB localization in response to DNA damage.

This study uses super-resolution imaging to show that E. coli SSB relocates from the inner membrane to the cell interior in response to DNA damage, forming foci for repair.